When Was The First Major League Baseball Game?
The first major league baseball game was played on October 3, 1845.
The first major league baseball game took place on April 22, 1876.
The first major league baseball game took place on April 22, 1876. The Cincinnati Reds played the Philadelphia Athletics, with the Reds winning by a score of 6-5. The game was played at Recreation Park in Philadelphia, and was attended by about 5,000 people.