Who Has The Most Interceptions Thrown In NFL History?

Peyton Manning holds the record for the most interceptions thrown in NFL history. In his career, he has thrown 251 interceptions.

Peyton Manning

Peyton Manning holds the record for the most interceptions thrown in NFL history. He has thrown for a total of 251 interceptions over the course of his career.

Brett Favre

Brett Favre has thrown the most interceptions in NFL history. He has thrown336 interceptions in his career, which is 19 more than the second person on the list, John Elway.

Drew Brees

Drew Brees is an American football quarterback for the New Orleans Saints of the National Football League (NFL). He played college football for Purdue University, and was chosen by the San Diego Chargers with the first pick in the second round of the 2001 NFL Draft. He left college as one of the most decorated players in Purdue and Big Ten Conference history, setting two NCAA records, 13 Big Ten Conference records, and 19 Purdue University records. As of 2019, he remains the Big Ten record-holder in several passing categories.

Tom Brady

As of the end of the 2019 season, New England Patriots quarterback Tom Brady has thrown the most interceptions in NFL history with 288. Brady, who was drafted by the Patriots in 2000, has played his entire career with the team. He is a six-time Super Bowl champion and three-time NFL MVP.

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