Who Has Thrown the Most Pick Sixes in NFL History?
Who has thrown the most Pick Sixes in NFL history? The answer might surprise you.
Peyton Manning
Peyton Manning, who played 18 seasons in the NFL, holds the record for the most pick sixes thrown in NFL history. He threw a total of 20 pick sixes during his career.
Brett Favre
Brett Favre has thrown the most pick sixes in NFL history. In his career, he has thrown 336 interceptions, which is also an NFL record. Of those, 36 have been returned for touchdowns by the opposing team.
Jameis Winston
Jameis Winston of the Tampa Bay Buccaneers has thrown the most pick sixes in NFL history with 23. In second place is Green Bay Packers quarterback Brett Favre with 22, followed by Peyton Manning of the Denver Broncos and New York Jets with 20 each.
Tom Brady
Tom Brady has thrown the most pick sixes in NFL history, with a total of 34. He is followed by Eli Manning, who has thrown 32, and Brett Favre, who has thrown 31. Peyton Manning has thrown 30 pick sixes, while Drew Brees has thrown 29.
